Nature Communications (Jul 2019)
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
- Masahiro Yoshida,
- Shunsuke Minagawa,
- Jun Araya,
- Taro Sakamoto,
- Hiromichi Hara,
- Kazuya Tsubouchi,
- Yusuke Hosaka,
- Akihiro Ichikawa,
- Nayuta Saito,
- Tsukasa Kadota,
- Nahoko Sato,
- Yusuke Kurita,
- Kenji Kobayashi,
- Saburo Ito,
- Hirohumi Utsumi,
- Hiroshi Wakui,
- Takanori Numata,
- Yumi Kaneko,
- Shohei Mori,
- Hisatoshi Asano,
- Makoto Yamashita,
- Makoto Odaka,
- Toshiaki Morikawa,
- Katsutoshi Nakayama,
- Takeo Iwamoto,
- Hirotaka Imai,
- Kazuyoshi Kuwano
Affiliations
- Masahiro Yoshida
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Shunsuke Minagawa
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Jun Araya
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Taro Sakamoto
- Laboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmaceutical Sciences, Kitasato University
- Hiromichi Hara
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Kazuya Tsubouchi
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Yusuke Hosaka
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Akihiro Ichikawa
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Nayuta Saito
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Tsukasa Kadota
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Nahoko Sato
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Yusuke Kurita
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Kenji Kobayashi
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Saburo Ito
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Hirohumi Utsumi
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Hiroshi Wakui
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Takanori Numata
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Yumi Kaneko
- Division of Chest Diseases, Department of Surgery, Jikei University School of Medicine
- Shohei Mori
- Division of Chest Diseases, Department of Surgery, Jikei University School of Medicine
- Hisatoshi Asano
- Division of Chest Diseases, Department of Surgery, Jikei University School of Medicine
- Makoto Yamashita
- Division of Chest Diseases, Department of Surgery, Jikei University School of Medicine
- Makoto Odaka
- Division of Chest Diseases, Department of Surgery, Jikei University School of Medicine
- Toshiaki Morikawa
- Division of Chest Diseases, Department of Surgery, Jikei University School of Medicine
- Katsutoshi Nakayama
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- Takeo Iwamoto
- Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Jikei University School of Medicine
- Hirotaka Imai
- Laboratory of Hygienic Chemistry and Medicinal Research Laboratories, School of Pharmaceutical Sciences, Kitasato University
- Kazuyoshi Kuwano
- Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10991-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in the pathogenesis of COPD.
