mCRPC progression of disease after [177Lu]Lu-PSMA-617 detected on [18F]Choline: a case of PCa heterogeneity

Riccardo Laudicella; Fabio Minutoli; Simona Russo; Massimiliano Siracusa; Michelangelo Bambaci; Benedetta Pagano; Sergio Baldari

Urology Case Reports (May 2024)

mCRPC progression of disease after [177Lu]Lu-PSMA-617 detected on [18F]Choline: a case of PCa heterogeneity

Riccardo Laudicella,
Fabio Minutoli,
Simona Russo,
Massimiliano Siracusa,
Michelangelo Bambaci,
Benedetta Pagano,
Sergio Baldari

Affiliations

Riccardo Laudicella: Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98121, Italy; Corresponding author. via consolare valeria n.1, Messina, ME, 98121, Italy.
Fabio Minutoli: Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98121, Italy
Simona Russo: Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98121, Italy
Massimiliano Siracusa: Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98121, Italy
Michelangelo Bambaci: Nuclear Medicine Unit, Humanitas Istituto Clinico Catanese, Misterbianco, 95045, Italy
Benedetta Pagano: Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98121, Italy
Sergio Baldari: Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and of Morpho-Functional Imaging, University of Messina, 98121, Italy

Journal volume & issue: Vol. 54
p. 102750

Abstract

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Radioligand therapy with [177Lu]Lu-PSMA is a theranostic approach for heavily treated mCRPC patients with positive PSMA PET in the absence of relevant PSMA-negative metastases assessed through CT, MRI, bone scan or FDG PET. In this case, we described a mCRPC patient treated with RLT with discordant PSA values and PSMA images, in which Choline PET confirmed a biochemically suspected disease progression (PD), showing metastatic lesions not revealed by PSMA imaging.

Published in Urology Case Reports

ISSN: 2214-4420 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://www.urologycasereports.com/

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