Epigenetic modulation reveals differentiation state specificity of oncogene addiction

Mehwish Khaliq; Mohan Manikkam; Elisabeth D. Martinez; Mohammad Fallahi-Sichani

doi:10.1038/s41467-021-21784-2

Nature Communications (Mar 2021)

Epigenetic modulation reveals differentiation state specificity of oncogene addiction

Mehwish Khaliq,
Mohan Manikkam,
Elisabeth D. Martinez,
Mohammad Fallahi-Sichani

Affiliations

Mehwish Khaliq: Department of Biomedical Engineering, University of Virginia
Mohan Manikkam: Department of Biomedical Engineering, University of Virginia
Elisabeth D. Martinez: Department of Pharmacology, UT Southwestern Medical Center
Mohammad Fallahi-Sichani: Department of Biomedical Engineering, University of Virginia

DOI: https://doi.org/10.1038/s41467-021-21784-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Epigenetic mechanisms associated with the differentiation state of cancer cells and their heterogeneity influence tumor responses to oncogene-targeted therapies. In this study, the authors perform an epigenetic compound screen and single-cell analysis in BRAF-mutant melanoma cells to identify compounds that block three distinct drug-tolerant epigenetic states associated with either one of the lysine-specific histone demethylases Kdm1a or Kdm4b, or BET proteins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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