Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Yuan Yang; Ruizeng Luo; Shengyu Chao; Jiangtao Xue; Dongjie Jiang; Yun Hao Feng; Xin Dong Guo; Dan Luo; Jiaping Zhang; Zhou Li; Zhong Lin Wang

doi:10.1038/s41467-022-34716-5

Nature Communications (Nov 2022)

Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Yuan Yang,
Ruizeng Luo,
Shengyu Chao,
Jiangtao Xue,
Dongjie Jiang,
Yun Hao Feng,
Xin Dong Guo,
Dan Luo,
Jiaping Zhang,
Zhou Li,
Zhong Lin Wang

Affiliations

Yuan Yang: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Ruizeng Luo: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Shengyu Chao: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Jiangtao Xue: Institute of Engineering Medicine, Beijing Institute of Technology
Dongjie Jiang: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Yun Hao Feng: Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology
Xin Dong Guo: Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology
Dan Luo: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Jiaping Zhang: Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University)
Zhou Li: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Zhong Lin Wang: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-34716-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

The use of epidermal growth factor for wound healing is limited by transdermal permeability, reduction, and receptor desensitization. Here the authors develop a microneedle-based self-powered transcutaneous electrical stimulation system to overcome these challenges.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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