Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Andres Binolfi; Antonio Limatola; Silvia Verzini; Jonas Kosten; Francois-Xavier Theillet; Honor May Rose; Beata Bekei; Marchel Stuiver; Marleen van Rossum; Philipp Selenko

doi:10.1038/ncomms10251

Nature Communications (Jan 2016)

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Andres Binolfi,
Antonio Limatola,
Silvia Verzini,
Jonas Kosten,
Francois-Xavier Theillet,
Honor May Rose,
Beata Bekei,
Marchel Stuiver,
Marleen van Rossum,
Philipp Selenko

Affiliations

Andres Binolfi: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Antonio Limatola: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Silvia Verzini: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Jonas Kosten: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Francois-Xavier Theillet: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Honor May Rose: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Beata Bekei: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Marchel Stuiver: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Marleen van Rossum: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)
Philipp Selenko: Department of NMR-supported Structural Biology, In-Cell NMR Laboratory, Leibniz Institute of Molecular Pharmacology (FMP Berlin)

DOI: https://doi.org/10.1038/ncomms10251
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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α-synuclein is a protein linked to the occurrence of Parkinson's disease. Here, the authors use time-resolved in-cell NMR spectroscopy to study the repair of methionine-oxidized α-synuclein by endogenous cellular enzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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