Detection of measles vaccine virus and measles-specific immunoglobulin M in children vaccinated against measles-mumps-rubella during measles outbreak
Euri Seo,
Yun-Jung Chang,
Jae Woo Chung,
Yoon-Seok Chung,
Seong Yeon Park
Affiliations
Euri Seo
Department of Infection Control, Dongguk University Ilsan Hospital, Dongguk UniversityCollege of Medicine, Goyang, Republic of Korea; Department of Pediatrics, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea; Korea virus research institute, Center for Viral Immunology, Institue for Basic Science, South Korea
Yun-Jung Chang
Department of Infection Control, Dongguk University Ilsan Hospital, Dongguk UniversityCollege of Medicine, Goyang, Republic of Korea
Jae Woo Chung
Department of Infection Control, Dongguk University Ilsan Hospital, Dongguk UniversityCollege of Medicine, Goyang, Republic of Korea; Department of Laboratory Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea
Yoon-Seok Chung
Division of High-risk Pathogens, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea
Seong Yeon Park
Department of Infection Control, Dongguk University Ilsan Hospital, Dongguk UniversityCollege of Medicine, Goyang, Republic of Korea; Department of Infectious Diseases, Dongguk University Ilsan Hospital, Goyang, Republic of Korea; Corresponding author at: Department of Infectious Diseases, Dongguk University Ilsan Hospital, Dongguk-ro 27, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea.
Information regarding the detection perioid of measles vaccine virus (MeVV) RNA in human nasopharyngeal samples and measles-specific antibodies following measles-mumps-rubella (MMR) vaccination is limited. During contact tracing for a measles outbreak at a hospital in Republic of Korea, 4 out of 206 children vaccinated with MMR underwent real-time RT-PCR assay for measles and measles-specific antibodies test. Measles virus RNA was detected in 2 children, all of which was vaccine virus strain RNA (genotype A). In a healthy 27-month-old boy, MeVV RNA was detected 448 days after MMR vaccination. Measles-specific IgM was positive 1097 days following vaccination in a 4-year-old girl. MeVV RNA and measles-specific IgM were detected for a considerable period following primary MMR vaccination. Physicians should exercise caution when interpreting positive RT-PCR results for MeVV or measles-specific IgM from a child with measles-associated symptoms who has been recently vaccinated against measles.
