Nature Communications (May 2021)

The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

  • Yanyan Chen,
  • Yan Wang,
  • Juan Chen,
  • Wu Zuo,
  • Yong Fan,
  • Sijia Huang,
  • Yongmei Liu,
  • Guangming Chen,
  • Qing Li,
  • Jinsong Li,
  • Jian Wu,
  • Qian Bian,
  • Chenhui Huang,
  • Ming Lei

DOI
https://doi.org/10.1038/s41467-021-23550-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential to mice gametogenesis.