A Voxel-based Morphometric Analysis of Cerebral Gray Matter in Subcortical Ischemic Vascular Dementia Patients and Normal Aged Controls

International Journal of Medical Sciences. 2011;8(6):482-486

 

Journal Homepage

Journal Title: International Journal of Medical Sciences

ISSN: 1449-1907 (Online)

Publisher: Ivyspring International Publisher

LCC Subject Category: Medicine

Country of publisher: Australia

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Chuanming Li, Hanjian Du, Jian Zheng, Jian Wang

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

<p><b>BACKGROUND AND PURPOSE:</b> The present study was designed to detect the abnormalities of the cerebral grey-matter density in subcortical ischemic vascular dementia patients by FSL-VBM method to promote the early diagnosis of it.</p><p><b>METHODS: </b>Nine subcortical ischemic vascular dementia patients and nine age-matched normal controls underwent MRI brain structure scanning that was performed on a SIEMENS AVANTO 1.5 Tesla scanner and standard T1-weighted high-resolution anatomic scans of MPRAGE sequence were obtained. The 3-demensional MPRAGE images were processed with FSL-VBM package and the cerebral gray matter density was compared between the subcortical ischemic vascular dementia patients and normal controls.</p><p><b>RESULTS:</b> Compared with the normal control group, the cerebral gray matter density of subcortical ischemic vascular dementia patients was found significantly decreasing, including brain regions of thalamus, parietal lobe, frontal lobe and temporal lobe (<i>P</i>&#60;0.05).</p><p><b>CONCLUSIONS:</b> The cerebral gray matter density alterations have closed correlation with cognitive dysfunction in subcortical ischemic vascular dementia patient and can be detected by MRI. MRI has some potential value in the diagnosis of them.</p>