Cancers (Aug 2023)
Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer
- Valerio Renzelli,
- Marco Gallo,
- Lelio Morviducci,
- Giampiero Marino,
- Alberto Ragni,
- Enzo Tuveri,
- Antongiulio Faggiano,
- Rossella Mazzilli,
- Annalisa Natalicchio,
- Maria Chiara Zatelli,
- Monica Montagnani,
- Stefano Fogli,
- Dario Giuffrida,
- Antonella Argentiero,
- Romano Danesi,
- Stella D’Oronzo,
- Stefania Gori,
- Tindara Franchina,
- Antonio Russo,
- Matteo Monami,
- Laura Sciacca,
- Saverio Cinieri,
- Annamaria Colao,
- Angelo Avogaro,
- Graziano Di Cianni,
- Francesco Giorgino,
- Nicola Silvestris
Affiliations
- Valerio Renzelli
- Italian Association of Clinical Diabetologists, 00192 Rome, Italy
- Marco Gallo
- Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, Italy
- Lelio Morviducci
- Diabetology and Nutrition Unit, Department of Medical Specialities, ASL Roma 1, S. Spirito Hospital, 00193 Rome, Italy
- Giampiero Marino
- Internal Medicine Department, Ospedale dei Castelli, Asl Roma 6, 00040 Ariccia, Italy
- Alberto Ragni
- Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, Italy
- Enzo Tuveri
- Diabetology, Endocrinology and Metabolic Diseases Service, ASL-Sulcis, 09016 Iglesias, Italy
- Antongiulio Faggiano
- Endocrinology Unit, Department of Clinical & Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy
- Rossella Mazzilli
- Endocrinology Unit, Department of Clinical & Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy
- Annalisa Natalicchio
- Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70121 Bari, Italy
- Maria Chiara Zatelli
- Section of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy
- Monica Montagnani
- Department of Precision and Regenerative Medicine and Ionian Area, Section of Pharmacology, University of Bari Aldo Moro, 70121 Bari, Italy
- Stefano Fogli
- Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
- Dario Giuffrida
- Department of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, 95029 Catania, Italy
- Antonella Argentiero
- Medical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
- Romano Danesi
- Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
- Stella D’Oronzo
- Interdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy
- Stefania Gori
- Oncologia Medica, IRCCS Ospedale Don Calabria-Sacro Cuore di Negrar, 37024 Verona, Italy
- Tindara Franchina
- Medical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, 98122 Messina, Italy
- Antonio Russo
- Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90133 Palermo, Italy
- Matteo Monami
- Diabetology, Careggi University Hospital, University of Florence, 50134 Florence, Italy
- Laura Sciacca
- Department of Clinical and Experimental Medicine, Endocrinology Section, University of Catania, 95124 Catania, Italy
- Saverio Cinieri
- Medical Oncology Division, Breast Unit, Senatore Antonio Perrino Hospital, ASL Brindisi, 72100 Brindisi, Italy
- Annamaria Colao
- Endocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, 80138 Naples, Italy
- Angelo Avogaro
- Department of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, 35122 Padova, Italy
- Graziano Di Cianni
- Diabetes Unit, Livorno Hospital, 57100 Livorno, Italy
- Francesco Giorgino
- Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70121 Bari, Italy
- Nicola Silvestris
- Medical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, 98122 Messina, Italy
- DOI
- https://doi.org/10.3390/cancers15174237
- Journal volume & issue
-
Vol. 15,
no. 17
p. 4237
Abstract
There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.
Keywords
