CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses

Phillip M. Brailey; Lauren Evans; Juan Carlos López-Rodríguez; Anthony Sinadinos; Victoria Tyrrel; Gavin Kelly; Valerie O’Donnell; Peter Ghazal; Susan John; Patricia Barral

doi:10.1038/s41467-022-34532-x

Nature Communications (Nov 2022)

CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses

Phillip M. Brailey,
Lauren Evans,
Juan Carlos López-Rodríguez,
Anthony Sinadinos,
Victoria Tyrrel,
Gavin Kelly,
Valerie O’Donnell,
Peter Ghazal,
Susan John,
Patricia Barral

Affiliations

Phillip M. Brailey: The Peter Gorer Department of Immunobiology, King’s College London
Lauren Evans: The Peter Gorer Department of Immunobiology, King’s College London
Juan Carlos López-Rodríguez: The Peter Gorer Department of Immunobiology, King’s College London
Anthony Sinadinos: The Peter Gorer Department of Immunobiology, King’s College London
Victoria Tyrrel: School of Medicine, Cardiff University
Gavin Kelly: The Francis Crick Institute
Valerie O’Donnell: School of Medicine, Cardiff University
Peter Ghazal: School of Medicine, Cardiff University
Susan John: The Peter Gorer Department of Immunobiology, King’s College London
Patricia Barral: The Peter Gorer Department of Immunobiology, King’s College London

DOI: https://doi.org/10.1038/s41467-022-34532-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Modulation of metabolic pathways is linked to regulation of immune cells including macrophages. Here the authors identify a role for CD1d in the metabolic rewiring of macrophages, which alters responsiveness to innate stimuli.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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