Nature Communications (Mar 2022)
Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19
- Tanja Paul,
- Stephan Ledderose,
- Harald Bartsch,
- Na Sun,
- Sarah Soliman,
- Bruno Märkl,
- Viktoria Ruf,
- Jochen Herms,
- Marcel Stern,
- Oliver T. Keppler,
- Claire Delbridge,
- Susanna Müller,
- Guido Piontek,
- Yuki Schneider Kimoto,
- Franziska Schreiber,
- Tracy Ann Williams,
- Jens Neumann,
- Thomas Knösel,
- Heiko Schulz,
- Ria Spallek,
- Matthias Graw,
- Thomas Kirchner,
- Axel Walch,
- Martina Rudelius
Affiliations
- Tanja Paul
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Stephan Ledderose
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Harald Bartsch
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Na Sun
- Research Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München
- Sarah Soliman
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Bruno Märkl
- Institute of Pathology, University of Augsburg
- Viktoria Ruf
- Institute of Neuropathology, Ludwig-Maximilians University Munich
- Jochen Herms
- Institute of Neuropathology, Ludwig-Maximilians University Munich
- Marcel Stern
- Max von Pettenkofer Institut, Ludwig-Maximilians University Munich
- Oliver T. Keppler
- Max von Pettenkofer Institut, Ludwig-Maximilians University Munich
- Claire Delbridge
- Institute of Pathology, Division of Neuropathology, TUM School of Medicine, Technical University Munich
- Susanna Müller
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Guido Piontek
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Yuki Schneider Kimoto
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Franziska Schreiber
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Tracy Ann Williams
- Medizinische Klinik und Poliklinik IV, Klinikum der University Munich
- Jens Neumann
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Thomas Knösel
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Heiko Schulz
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Ria Spallek
- Medizinische Klinik und Poliklinik III, Technical University Munich
- Matthias Graw
- Institute of Forensic Medicine, Ludwig-Maximilians University Munich
- Thomas Kirchner
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- Axel Walch
- Research Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München
- Martina Rudelius
- Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich
- DOI
- https://doi.org/10.1038/s41467-022-29145-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Progressive respiratory failure is the primary cause of death in patients with COVID-19, but pathologies in other tissues may also occur. Here the authors report that adrenal tropism of SARS-CoV-2 is associated with adrenalitis, reduced adrenal cortisol levels and severe adrenal damage in a post-mortem case series of patients with severe fatal COVID-19.
