Frontiers in Medicine (Mar 2021)
Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome
- Alessandra G. D. Lopes,
- Camila S. H. Celestino,
- Tiago T. A. Barros,
- Tiago T. A. Barros,
- Aline G. Fevereiro,
- Debora H. Gejer,
- Fernando M. F. Oliveira,
- Jamile M. Brasil,
- Rosely M. Bossolan,
- Gabriela C. C. Pinto,
- Ana C. E. Z. Santos,
- Luis A. Divan,
- Ingrid A. B. Alves,
- Danielle B. L. Oliveira,
- Danielle B. L. Oliveira,
- Rafael R. G. Machado,
- Luciano M. Thomazelli,
- Meire I. Hiyane,
- Leonília Brelaz-Abreu,
- Elayne Bragança-Jardim,
- Letícia B. S. Heinen,
- Anna C. M. Barrientos,
- Luciana B. Mau,
- Niels O. S. Camara,
- Daniela F. Bueno,
- Daniela F. Bueno,
- Mariane T. Amano
Affiliations
- Alessandra G. D. Lopes
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Camila S. H. Celestino
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Tiago T. A. Barros
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Tiago T. A. Barros
- Hospital Sírio-Libanês, São Paulo, Brazil
- Aline G. Fevereiro
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Debora H. Gejer
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Fernando M. F. Oliveira
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Jamile M. Brasil
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Rosely M. Bossolan
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Gabriela C. C. Pinto
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Ana C. E. Z. Santos
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Luis A. Divan
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Ingrid A. B. Alves
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Danielle B. L. Oliveira
- Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
- Danielle B. L. Oliveira
- Hospital Israelita Albert Einstein, São Paulo, Brazil
- Rafael R. G. Machado
- Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
- Luciano M. Thomazelli
- Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
- Meire I. Hiyane
- Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
- Leonília Brelaz-Abreu
- Hospital Sírio-Libanês, São Paulo, Brazil
- Elayne Bragança-Jardim
- Hospital Sírio-Libanês, São Paulo, Brazil
- Letícia B. S. Heinen
- Hospital Sírio-Libanês, São Paulo, Brazil
- Anna C. M. Barrientos
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Luciana B. Mau
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Niels O. S. Camara
- Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
- Daniela F. Bueno
- Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil
- Daniela F. Bueno
- Hospital Sírio-Libanês, São Paulo, Brazil
- Mariane T. Amano
- Hospital Sírio-Libanês, São Paulo, Brazil
- DOI
- https://doi.org/10.3389/fmed.2021.629112
- Journal volume & issue
-
Vol. 8
Abstract
Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection.
Keywords