Nature Communications (Dec 2017)

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

  • Esmaeil Dehghan,
  • Yiqiang Zhang,
  • Bahar Saremi,
  • Sivaramakrishna Yadavali,
  • Amirmansoor Hakimi,
  • Maryam Dehghani,
  • Mohammad Goodarzi,
  • Xiaoqin Tu,
  • Scott Robertson,
  • Rueyling Lin,
  • Asish Chudhuri,
  • Hamid Mirzaei

DOI
https://doi.org/10.1038/s41467-017-02394-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-associated diseases more broadly.