Microwave assisted synthesis of 2-(2-(tetrazolo[1,5-a]quinolin-4-yl)-2,3-dihydro-1h-benzo[b][1,4]diazepin-4-yl) substituted phenols and evaluation of their antimicrobial activity

Abstract

A series of new benzodiazepines 4a-h have been synthesized by Michael addition of chalcones 3a-h with o-phenylenediamine (OPDA) in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized benzodiazepines 4a-h have been established on the basis of IR, 1H & 13C NMR and mass spectral data and tested for antimicrobial activity.

Keywords

• Antimicrobial activity
• benzodiazepines
• chalcones
• Michael addition
• microwave irradiation
• tetrazolo quinoline aldehyde