Estimating severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence from residual clinical blood samples, January–March 2021

Daniel S. Graciaa; Hans P. Verkerke; Jeannette Guarner; Ana Maria Moldoveanu; Narayanaiah Cheedarla; Connie M. Arthur; Cheryl L. Maier; Andrew Neish; Sara C. Auld; Angie Campbell; Neel R. Gandhi; John D. Roback; N. Sarita Shah

doi:10.1017/ash.2022.298

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2022)

Estimating severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence from residual clinical blood samples, January–March 2021

Daniel S. Graciaa,
Hans P. Verkerke,
Jeannette Guarner,
Ana Maria Moldoveanu,
Narayanaiah Cheedarla,
Connie M. Arthur,
Cheryl L. Maier,
Andrew Neish,
Sara C. Auld,
Angie Campbell,
Neel R. Gandhi,
John D. Roback,
N. Sarita Shah

Affiliations

Daniel S. Graciaa: ORCiD; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Hans P. Verkerke: Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
Jeannette Guarner: Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
Ana Maria Moldoveanu: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Narayanaiah Cheedarla: ORCiD; Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
Connie M. Arthur: Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Cheryl L. Maier: ORCiD; Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
Andrew Neish: Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
Sara C. Auld: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Angie Campbell: ORCiD; Departments of Epidemiology and Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia
Neel R. Gandhi: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia Departments of Epidemiology and Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia
John D. Roback: ORCiD; Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
N. Sarita Shah: ORCiD; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia Departments of Epidemiology and Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia

DOI: https://doi.org/10.1017/ash.2022.298
Journal volume & issue: Vol. 2

Abstract

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We describe severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG seroprevalence and antigenemia among patients at a medical center in January–March 2021 using residual clinical blood samples. The overall seroprevalences were 17% by infection and 16% by vaccination. Spent or residual samples are a feasible alternative for rapidly estimating seroprevalence or monitoring trends in infection and vaccination.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

About the journal