Sauchinone, an active phytochemical of Saururus Chinensis, and its use as therapeutic

Abstract

Introduction: Saururus chinensis (Saururaceae) is an important medicinal plant used in traditional Chinese and Korean medicine to treat human diseases. Sauchinone, a lignin from Saururus chinensis, is reported to have numerous pharmacological applications in medicine, including anti-oxidant, anti-inflammatory, anti-apoptotic, anti-obesity, and hepatoprotective effects. Methods: The purpose of this review article is to describe the scientific information about sauchinone, its medical importance and pharmacological activity in order to explore the potential health benefits of sauchinone in medicine. In this review, all the scientific information about sauchinone was collected from PubMed, Scopus, Science Direct, Google, and Google Scholar. Additionally, this review also described the pharmacokinetics of sauchinone in order to understand the plasma drug profile of sauchinone with their molecular docking studies. Results: Scientific evidence in this review article described the biological importance of sauchinone in medicine against breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, liver cancer, lung adenocarcinoma, pancreatic ductal adenocarcinoma, osteosarcoma, diabetes, ulcerative colitis, inflammatory bowel disease, osteoarthritis, liver disorders and other human complications. Additionally, molecular docking studies, and pharmacokinetics parameters of sauchinone were also presented in this review to know their therapeutic value in medicine. However, molecular mechanisms of sauchinone were also described in the present review in order to know their biological significance in different kinds of human complications. Discussion: The scientific evidence in this article demonstrates the medicinal importance and the molecular mechanisms involved in the pharmacological activities of sauchinone in medicine. However, detailed preclinical and clinical data are still needed in scientific research to declare the therapeutic efficacy of sauchinone against human diseases.

Keywords

• Cancer
• Sauchinone
• Saururus chinensis
• Pharmacokinetic
• Pharmacological
• Phytochemical