In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

Abstract

Highlights A multifactorial and oriented scaffolds was constructed to stimulate osteochondral regeneration. This is the first demonstration that both drug and gene nanoparticles were spatially deposited on a patterned film through metal-ligand interactions. For the first time, film-rolling approach was employed to construct osteochondral plug to mimick the Haversian canal structure of natural bone.

Keywords

• Osteochondral regeneration
• Oriented hydrogel
• Kartogenin
• miRNA-26a