Nature Communications (Nov 2021)

PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells

  • Susanne Prokop,
  • Péter Ábrányi-Balogh,
  • Benjámin Barti,
  • Márton Vámosi,
  • Miklós Zöldi,
  • László Barna,
  • Gabriella M. Urbán,
  • András Dávid Tóth,
  • Barna Dudok,
  • Attila Egyed,
  • Hui Deng,
  • Gian Marco Leggio,
  • László Hunyady,
  • Mario van der Stelt,
  • György M. Keserű,
  • István Katona

DOI
https://doi.org/10.1038/s41467-021-26757-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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The authors introduce PharmacoSTORM single-molecule imaging that uses fluorescent ligands and immunolabeling for cellular and subcellular nanoscale molecular pharmacology. They demonstrate its capabilities by visualizing cariprazine binding to D3 dopamine receptors on Islands of Calleja granule cell axons.