Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products

Abstract

In recent decades, avian antibody technology has become more popular in the medical field, successfully replacing the immunoglobulins obtained from mammals. Y antibodies (IgY) are extracted from the yolk of hyperimmune eggs harvested from hens (Gallus domesticus) immunized with different antigens and have an already proven applicability in various medical fields such as the manufacture of diagnostic kits and the development of passive antibody therapy protocols for various infectious diseases. It is well known that avian immunoglobulin therapy is effective in the prevention and treatment of bacterial diseases in humans and animals, especially with gastrointestinal localization. In the present study, the production of avian immunoglobulins with antiviral activity, their extraction, and purification, as well as the formulation of therapeutic products for administration to human patients exhibiting clinically symptomatic infections with rotavirus, Herpes simplex virus type 1, human papillomavirus or Varicella zoster virus. These are highly pathogenic viruses, leading to significant human morbidity and mortality, for which the therapeutic options are currently quite limited.