INTERACTION OF IRON-CONTAINING NANOCLUSTER POLYOXOMETALATE WITH DOXORUBICIN

Abstract

Actual problem in the field of targeted drug delivery is transport of highly toxic drugs, with undesirable side effects, in particular antitumor medicine. The thermodynamic parameters of complexation between nanocluster polyoxometalate {Mo72Fe30}, promising as a means of targeted drug delivery, and a cytostatic agent – doxorubicin, widely used in clinical practice, were studied. The interaction of doxorubicin with {Mo72Fe30} was accompanied by an exothermic effect, which indicates an energetically favorable formation of the complex. The kinetics of the release of doxorubicin from the complex in a buffer solution with a pH corresponding to the pH value of blood was studied by fluorescence spectroscopy. The rate constants of destruction processes in the complex, accompanied by the release of doxorubicin, and further complexation of the released doxorubicin with decay products were determined. In the future, it is possible to slow down the release of doxorubicin by stabilizing the {Mo72Fe30}, for example, when it is associated with albumin.

Keywords

• nanocluster polyoxometalates
• doxorubicin
• complexation
• targeted delivery
• nanoparticles
• rate constant
• thermodynamic parameters