Nature Communications (Aug 2022)
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
- Tomoya Isobe,
- Masatoshi Takagi,
- Aiko Sato-Otsubo,
- Akira Nishimura,
- Genta Nagae,
- Chika Yamagishi,
- Moe Tamura,
- Yosuke Tanaka,
- Shuhei Asada,
- Reina Takeda,
- Akiho Tsuchiya,
- Xiaonan Wang,
- Kenichi Yoshida,
- Yasuhito Nannya,
- Hiroo Ueno,
- Ryo Akazawa,
- Itaru Kato,
- Takashi Mikami,
- Kentaro Watanabe,
- Masahiro Sekiguchi,
- Masafumi Seki,
- Shunsuke Kimura,
- Mitsuteru Hiwatari,
- Motohiro Kato,
- Shiro Fukuda,
- Kenji Tatsuno,
- Shuichi Tsutsumi,
- Akinori Kanai,
- Toshiya Inaba,
- Yusuke Shiozawa,
- Yuichi Shiraishi,
- Kenichi Chiba,
- Hiroko Tanaka,
- Rishi S. Kotecha,
- Mark N. Cruickshank,
- Fumihiko Ishikawa,
- Tomohiro Morio,
- Mariko Eguchi,
- Takao Deguchi,
- Nobutaka Kiyokawa,
- Yuki Arakawa,
- Katsuyoshi Koh,
- Yuki Aoki,
- Takashi Ishihara,
- Daisuke Tomizawa,
- Takako Miyamura,
- Eiichi Ishii,
- Shuki Mizutani,
- Nicola K. Wilson,
- Berthold Göttgens,
- Satoru Miyano,
- Toshio Kitamura,
- Susumu Goyama,
- Akihiko Yokoyama,
- Hiroyuki Aburatani,
- Seishi Ogawa,
- Junko Takita
Affiliations
- Tomoya Isobe
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Masatoshi Takagi
- Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
- Aiko Sato-Otsubo
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Akira Nishimura
- Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
- Genta Nagae
- Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo
- Chika Yamagishi
- Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
- Moe Tamura
- Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Yosuke Tanaka
- Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo
- Shuhei Asada
- Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo
- Reina Takeda
- Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo
- Akiho Tsuchiya
- Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo
- Xiaonan Wang
- Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge
- Kenichi Yoshida
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Yasuhito Nannya
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Hiroo Ueno
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Ryo Akazawa
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
- Itaru Kato
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
- Takashi Mikami
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
- Kentaro Watanabe
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Masahiro Sekiguchi
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Masafumi Seki
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Shunsuke Kimura
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Mitsuteru Hiwatari
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Motohiro Kato
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Shiro Fukuda
- Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo
- Kenji Tatsuno
- Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo
- Shuichi Tsutsumi
- Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo
- Akinori Kanai
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Toshiya Inaba
- Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University
- Yusuke Shiozawa
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Yuichi Shiraishi
- Division of Genome Analysis Platform Development, National Cancer Center Research Institute
- Kenichi Chiba
- Division of Genome Analysis Platform Development, National Cancer Center Research Institute
- Hiroko Tanaka
- Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University
- Rishi S. Kotecha
- Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia
- Mark N. Cruickshank
- School of Biomedical Sciences, University of Western Australia
- Fumihiko Ishikawa
- Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences
- Tomohiro Morio
- Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
- Mariko Eguchi
- Department of Pediatrics, Ehime University Graduate School of Medicine
- Takao Deguchi
- Division of Cancer Immunodiagnostics, Children’s Cancer Center, National Center for Child Health and Development
- Nobutaka Kiyokawa
- Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development
- Yuki Arakawa
- Department of Hematology/Oncology, Saitama Children’s Medical Center
- Katsuyoshi Koh
- Department of Hematology/Oncology, Saitama Children’s Medical Center
- Yuki Aoki
- Department of Pediatric Oncology, National Cancer Center Japan
- Takashi Ishihara
- Department of Pediatrics, Nara Medical University
- Daisuke Tomizawa
- Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development
- Takako Miyamura
- Department of Pediatrics, Osaka University Graduate School of Medicine
- Eiichi Ishii
- Department of Pediatrics, Ehime University Graduate School of Medicine
- Shuki Mizutani
- Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
- Nicola K. Wilson
- Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge
- Berthold Göttgens
- Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge
- Satoru Miyano
- Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University
- Toshio Kitamura
- Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo
- Susumu Goyama
- Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Akihiko Yokoyama
- Tsuruoka Metabolomics Laboratory, National Cancer Center
- Hiroyuki Aburatani
- Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo
- Seishi Ogawa
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Junko Takita
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-022-32266-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and personalised treatment.’
