Clinical usefulness of serum neopterin in children with juvenile idiopathic arthritis
Plata-Nazar Katarzyna,
Szumera Małgorzata,
Łuczak Grażyna,
Liberek Anna,
Sznurkowska Katarzyna,
Szlagatys-Sidorkiewicz Agnieszka,
Lange Magdalena,
Kamińska Barbara
Affiliations
Plata-Nazar Katarzyna
Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, 1-6 Nowe Ogrody St., 80-803 Gdansk, Poland
Szumera Małgorzata
Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, 1-6 Nowe Ogrody St., 80-803 Gdansk, Poland
Łuczak Grażyna
Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, 1-6 Nowe Ogrody St., 80-803 Gdansk, Poland
Liberek Anna
Faculty of Health Sciences with Subfaculty of Nursing, Medical University of Gdansk, 3a Sklodowskiej-Curie Str, 80-210, Gdansk, Poland
Sznurkowska Katarzyna
Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, 1-6 Nowe Ogrody St., 80-803 Gdansk, Poland
Szlagatys-Sidorkiewicz Agnieszka
Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, 1-6 Nowe Ogrody St., 80-803 Gdansk, Poland
Lange Magdalena
Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 3a Sklodowskiej-Curie Str, 80-210, Gdansk, Poland
Kamińska Barbara
Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, 1-6 Nowe Ogrody St., 80-803 Gdansk, Poland
The aim of this study was to analyze the usefulness of the serum concentration of neopterin (NPT) as a marker of juvenile idiopathic arthritis (JIA). The study included 67 children with JIA (36 girls and 31 boys), aged between 3.8 and 17.9 years (mean 13.7±3.4 years), and 105 healthy controls (47 girls and 58 boys) of similar age, with no evidence of acute or chronic inflammation. Serum NPT was determined immunoenzymatically. The median serum concentration of NPT and prevalence of elevated serum NPT (>11 nmol/L) were significantly higher in children with JIA than in the controls: 6.044 vs. 4.734 nmol/L (p11 nmol/L (50% vs. 0%, p<0.001) than did patients with remission. These data suggest that elevated serum concentration of NPT is an accurate marker of JIA exacerbation.
