Changes in expression of estrogen-regulatory genes in malignancy uterine tissues

Abstract

We investigated the relative expression of genes responsible for the estrogen reception and metabolism - CYP1A 1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER, STS, SULT1A and SULT1E1 - by real-time PCR in tumor and conditionally healthy uterine tissues of 27 female patients in Southern Russia aged 38-72 years with histologically confirmed diagnosis of uterine cancer. It is found that transcription activity of these genes during malignancy of uterine tissues depends of female patients age and the stage of tumor cells differentiation. It is potentially allow to use investigated genes as biomarkers of uterine tissues malignancy with considering age features of female patients and stages of cancer process development.

Keywords

• экспрессия генов
• рак тела матки
• метаболизм эстрогенов
• gene expression
• uterine cancer
• estrogen metabolism