The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Abstract

Kang Li,1,2,* Xianhai Zeng,1,2,* Peng Liu,1,2 Xiaoxia Zeng,2 Jie Lv,3 Shuqi Qiu,1,2 Peng Zhang1,2 1Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai Campus, Zhuhai, Guangdong, People’s Republic of China; 2Department of Otorhinolaryngology, Longgang Otorhinolaryngology Hospital & Shenzhen Key Laboratory of Otorhinolaryngology, Shenzhen Institute of Otorhinolaryngology, Shenzhen, Guangdong, People’s Republic of China; 3School of Computer Science and Engineering, Yulin Normal University, Yulin, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuqi Qiu; Peng Zhang, Longgang Otorhinolaryngology Hospital & Shenzhen Key Laboratory of Otorhinolaryngology, Shenzhen Institute of Otorhinolaryngology, No. 3004 Longgang Avenue, Shenzhen, Guangdong, People’s Republic of China, Tel [phone], Fax [phone], Email [email protected]; [email protected]: Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.Keywords: inflammation, head and neck squamous cell carcinoma, HNSCC, mediators, progression, therapy

Keywords

• inflammation
• head and neck squamous cell carcinoma ;hnscc
• mediators
• progression
• therapy