Nature Communications (Jan 2023)

Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning

  • Liping Huang,
  • Hongwei Sun,
  • Liangbin Sun,
  • Keqing Shi,
  • Yuzhe Chen,
  • Xueqian Ren,
  • Yuancai Ge,
  • Danfeng Jiang,
  • Xiaohu Liu,
  • Wolfgang Knoll,
  • Qingwen Zhang,
  • Yi Wang

DOI
https://doi.org/10.1038/s41467-022-35696-2
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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Biopsy is recommended for definitive diagnosis of liver carcinoma, however, this process requires staining and expert pathologists to confirm diagnosis. Here, the authors employ a portable Raman spectroscopy system combined with deep learning to detect carcinoma from normal tissue in real time.