Nature Communications (Jul 2021)
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
- Katsura Minegishi,
- Benjamin Rothé,
- Kaoru R. Komatsu,
- Hiroki Ono,
- Yayoi Ikawa,
- Hiromi Nishimura,
- Takanobu A. Katoh,
- Eriko Kajikawa,
- Xiaorei Sai,
- Emi Miyashita,
- Katsuyoshi Takaoka,
- Kana Bando,
- Hiroshi Kiyonari,
- Tadashi Yamamoto,
- Hirohide Saito,
- Daniel B. Constam,
- Hiroshi Hamada
Affiliations
- Katsura Minegishi
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Benjamin Rothé
- Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences
- Kaoru R. Komatsu
- Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
- Hiroki Ono
- Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yayoi Ikawa
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Hiromi Nishimura
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Takanobu A. Katoh
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Eriko Kajikawa
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Xiaorei Sai
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Emi Miyashita
- Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
- Katsuyoshi Takaoka
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- Kana Bando
- Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
- Hiroshi Kiyonari
- Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
- Tadashi Yamamoto
- Laboratory for Immunogenetics, Center for Integrative Medical Sciences
- Hirohide Saito
- Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University
- Daniel B. Constam
- Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences
- Hiroshi Hamada
- Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research
- DOI
- https://doi.org/10.1038/s41467-021-24295-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dand5 by Bicc1.
