Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution

Abstract

2-(hetero)aryl N-heteroarenes are ubiquitously applied in numerous fields of science and useful for the development of bioactive molecules and drugs, but there is a lack of general methods for their synthesis. Here, the authors report an iridium(III)-catalyzed method for direct α-arylation of N-heteroarenes with aryl and heteroaryl boronic acids, by a H2O-mediated H2-evolution cross-coupling strategy.