Brain Research Bulletin (Sep 2022)
Nervous system manifestations related to COVID-19 and their possible mechanisms
- Zhen Xie,
- Hao Hui,
- Zhihan Zhao,
- Wenjin Yu,
- Rui Wu,
- Yanzhao Zhu,
- Yuan Song,
- Bingqing Cao,
- Wenzhen Shi,
- Di Zhao,
- Yunsong Zhao,
- Junchao Lv,
- Qian Yao,
- Yan Duan,
- Jingwen Li,
- Haijun Zhang,
- Linfu Zhou,
- Xiaotian Wang,
- Ye Tian,
- Gang Zhao
Affiliations
- Zhen Xie
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China; Medical Research Center; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, No.10 Eastern section of the third FengCheng Rd., WeiYang District, Xi’an City, Shaanxi Province, P.R. China
- Hao Hui
- Department of Spine Surgery, Honghui Hospital, The Affiliated Hospital of Xi’an Jiaotong University, No. 555 Youyi East Road, Xi’an, Shaanxi 710054, PR China
- Zhihan Zhao
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China
- Wenjin Yu
- Department of Neurology, Yan’an University Medical College No. 3 Affiliated Hospital, Xianyang, China
- Rui Wu
- Department of Neurology, Xijing Hospital, Air Force Medical University, No. 15 Changle West Road, Xi’an, Shaanxi 710032, PR China
- Yanzhao Zhu
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China
- Yuan Song
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China
- Bingqing Cao
- The No.2 Department of Neurology, Shaanxi Provincial People’s Hospital, No.256 Youyi West Road, Xi’an, Shaanxi 710068, PR China
- Wenzhen Shi
- Medical Research Center; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, No.10 Eastern section of the third FengCheng Rd., WeiYang District, Xi’an City, Shaanxi Province, P.R. China
- Di Zhao
- Department of Neurology, Xijing Hospital, Air Force Medical University, No. 15 Changle West Road, Xi’an, Shaanxi 710032, PR China
- Yunsong Zhao
- Department of Neurology, Xijing Hospital, Air Force Medical University, No. 15 Changle West Road, Xi’an, Shaanxi 710032, PR China
- Junchao Lv
- Department of Neurology, Xijing Hospital, Air Force Medical University, No. 15 Changle West Road, Xi’an, Shaanxi 710032, PR China
- Qian Yao
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China
- Yan Duan
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China
- Jingwen Li
- Department of Neurology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2000 Xiang'an East Road, Xiamen, Fujian 361101, PR China
- Haijun Zhang
- Department of Neurology, Xijing Hospital, Air Force Medical University, No. 15 Changle West Road, Xi’an, Shaanxi 710032, PR China
- Linfu Zhou
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China
- Xiaotian Wang
- School of Information and Communication Engineering, Xi'an Jiaotong University, No.28 Xianning West Road, Xi’an 710049, PR China
- Ye Tian
- Medical Research Center; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, No.10 Eastern section of the third FengCheng Rd., WeiYang District, Xi’an City, Shaanxi Province, P.R. China; Corresponding authors.
- Gang Zhao
- The College of Life Sciences and Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China; Corresponding authors.
- Journal volume & issue
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Vol. 187
pp. 63 – 74
Abstract
In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.
