Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp
Roland Nathan Mandal,
Jing Ke,
Nusrat Hasan Kanika,
Fuyan Wang,
Jun Wang,
Chenghui Wang
Affiliations
Roland Nathan Mandal
Key Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University
Jing Ke
Key Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University
Nusrat Hasan Kanika
Key Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University
Fuyan Wang
Key Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University
Jun Wang
Key Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University
Chenghui Wang
Key Laboratory of Freshwater Aquatic Genetic Resources Certificated By the Ministry of Agriculture and Rural Affairs, Shanghai Engineering Research Center of Aquaculture, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University
Abstract Background Neither a TYRP1-mediated highly conserved genetic network underlying skin color towards optimum defense nor the pathological tendency of its mutation is well understood. The Oujiang Color Common Carp (Cyprinus carpio var. color) as a model organism, offering valuable insights into genetics, coloration, aquaculture practices, and environmental health. Here, we performed a comparative skin transcriptome analysis on TYRP1 mutant and wild fishes by applying a conservative categorical approach considering different color phenotypes. Results Our results reveal that an unusual color phenotype may be sensitized with TYRP1 mutation as a result of upregulating several genes related to an anti-inflammatory autoimmune system in response to the COMT-mediated catecholamine neurotransmitters in the skin. Particularly, catecholamines-derived red/brown, red with blue colored membrane attack complex, and brown/grey colored reduced eumelanin are expected to be aggregated in the regenerated cells. Conclusions It is, thus, concluded that the regenerated cells with catecholamines, membrane attack complex, and eumelanin altogether may contribute to the formation of the unusual (coffee-like) color phenotype in TYRP1 mutant.
