Effects of polyphenolic-rich extracts from Citrus hystrix on proliferation and oxidative stress in breast and colorectal cancer

Abstract

The anti-proliferative effects of Citrus hystrix have been reported. However, information on breast and colorectal cancer is limited especially the mechanistic aspects. In this study, the antioxidant activities of hexane, ethyl acetate, methanol and water extracts of C. hystrix leaves and their growth inhibitory effects on colorectal (HCT 116) and breast cancer (MCF 7, MDA-MB 231 and HCC 1937) cells were analysed.

Keywords

• anti-proliferative
• apoptosis
• breast cancer
• caspase
• citrus hystrix
• colorectal cancer
• oxidative stress