The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

Mashito Sakai; Tomoko Tujimura-Hayakawa; Takashi Yagi; Hiroyuki Yano; Masaru Mitsushima; Hiroyuki Unoki-Kubota; Yasushi Kaburagi; Hiroshi Inoue; Yoshiaki Kido; Masato Kasuga; Michihiro Matsumoto

doi:10.1038/ncomms13147

Nature Communications (Nov 2016)

The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

Mashito Sakai,
Tomoko Tujimura-Hayakawa,
Takashi Yagi,
Hiroyuki Yano,
Masaru Mitsushima,
Hiroyuki Unoki-Kubota,
Yasushi Kaburagi,
Hiroshi Inoue,
Yoshiaki Kido,
Masato Kasuga,
Michihiro Matsumoto

Affiliations

Mashito Sakai: Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Tomoko Tujimura-Hayakawa: Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Takashi Yagi: Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Hiroyuki Yano: Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Masaru Mitsushima: Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Hiroyuki Unoki-Kubota: Department of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Yasushi Kaburagi: Department of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Hiroshi Inoue: Metabolism and Nutrition Research Unit, Innovative Integrated Bio-research Core, Institute for Frontier Science Initiative, Kanazawa University
Yoshiaki Kido: Division of Medical Chemistry, Department of Metabolism and Disease, Kobe University Graduate School of Health Sciences
Masato Kasuga: National Center for Global Health and Medicine
Michihiro Matsumoto: Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine

DOI: https://doi.org/10.1038/ncomms13147
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phosphorylation at S275 by PKA in a CITED2-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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