Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR

• Lamya H. Al-Wahaibi,
• Safwat M. Rabea,
• Mohamed A. Mahmoud,
• Bahaa G.M. Youssif,
• Stefan Bräse,
• Salah A. Abdel-Aziz

Affiliations

Lamya H. Al-Wahaibi

Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Safwat M. Rabea

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

Mohamed A. Mahmoud

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Bahaa G.M. Youssif

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Stefan Bräse

Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe, Germany

Salah A. Abdel-Aziz

Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Assiut, Egypt