Scanning tunneling spectroscopy of homooligonucleotides

Abstract

Short single-stranded DNA molecules of two types, consisting of dC nucleotides only or dA nucleotides only, were immobilized onto the surface of mica and silver substrates and studied by scanning probe microscopy methods. Geometric dimensions of the studied objects were determined. The currentvoltage curves of d(A)12 and d(C)12 oligonucleotides were measured. Their differential electrical resistances were estimated and compared with each other.

Keywords

• oligonucleotide;
• current-voltage curve;
• atomic force microscopy;
• electrical resistance;
• dna;
• scanning tunneling microscopy