One-Pot solvent-free synthesis of Highly Substituted Imidazoles catalyzed by zeolite

Abstract

A series of tri- and tetra- substituted imidazoles were synthesized from benzyl, aldehyde and ammonium acetate in the presence of zeolite as an ecofriendly reusable catalyst under microwave irradiation in the absence of solvent. The yields are high to excellent and the use of microwave irradiation reduces reaction times to few minute.

Keywords

• Zeolite
• One-pot synthesis
• Solvent-free
• Trisubstituted imidazoles
• Tetrasubstituted imidazoles