The Neuroimmunologic Approach to Tension Type Headache and Migraine

Abstract

OBJECTIVE: The immunologic studies that investigate pat- hogenesis of tension type headache are going on. Although the studies about interleukines, TNF-α, IgG, complemans and NO were reported, the parameters like MIP-1α, RANTES, eotaxin and endotelin-1 (ET-1) ha- ven’t been studied yet METHODS: The aim of our study was investigated the role of TNF-α, IL- 6, NO and MIP-1α, RANTES, eotaxin and ET-1 at the pathogenesis of tension type headache and compared these parameters with migraine patients. RESULTS: The level of these parameters were measured during headache period and headache free period at 72 patients with tension type headache (32 of them episodic and 40 of them chronic type), 58 patients with migraine (30 of them with aura and 28 of them without aura) and 30 healthy patients. CONCLUSION: It was founded that TNF-α, IL-6, NO, MIP-1α, RANTES, eotaxin and ET-1 levels were increased at the patients with tension type headac- he and migraine during the headache period when was compared with control group and the patients in headache free period. These results can be thought that they are similarity in ne- uroimmunologic reactions between tension type and and MIP-1α, RANTES, eotaxin and ET-1 could be have a role in pathogenesis of ten- sion type headache

Keywords

• Tension type headache
• pathophysiology
• cytokine
• chemokine