Nature Communications (Jan 2020)
Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
- Megan M. Weivoda,
- Chee Kian Chew,
- David G. Monroe,
- Joshua N. Farr,
- Elizabeth J. Atkinson,
- Jennifer R. Geske,
- Brittany Eckhardt,
- Brianne Thicke,
- Ming Ruan,
- Amanda J. Tweed,
- Louise K. McCready,
- Robert A. Rizza,
- Aleksey Matveyenko,
- Moustapha Kassem,
- Thomas Levin Andersen,
- Adrian Vella,
- Matthew T. Drake,
- Bart L. Clarke,
- Merry Jo Oursler,
- Sundeep Khosla
Affiliations
- Megan M. Weivoda
- Mayo Clinic College of Medicine and Science
- Chee Kian Chew
- Mayo Clinic College of Medicine and Science
- David G. Monroe
- Mayo Clinic College of Medicine and Science
- Joshua N. Farr
- Mayo Clinic College of Medicine and Science
- Elizabeth J. Atkinson
- Mayo Clinic College of Medicine and Science
- Jennifer R. Geske
- Mayo Clinic College of Medicine and Science
- Brittany Eckhardt
- Mayo Clinic College of Medicine and Science
- Brianne Thicke
- Mayo Clinic College of Medicine and Science
- Ming Ruan
- Mayo Clinic College of Medicine and Science
- Amanda J. Tweed
- Mayo Clinic College of Medicine and Science
- Louise K. McCready
- Mayo Clinic College of Medicine and Science
- Robert A. Rizza
- Mayo Clinic College of Medicine and Science
- Aleksey Matveyenko
- Mayo Clinic College of Medicine and Science
- Moustapha Kassem
- University of Southern Denmark
- Thomas Levin Andersen
- University of Southern Denmark
- Adrian Vella
- Mayo Clinic College of Medicine and Science
- Matthew T. Drake
- Mayo Clinic College of Medicine and Science
- Bart L. Clarke
- Mayo Clinic College of Medicine and Science
- Merry Jo Oursler
- Mayo Clinic College of Medicine and Science
- Sundeep Khosla
- Mayo Clinic College of Medicine and Science
- DOI
- https://doi.org/10.1038/s41467-019-14003-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may be a factor coupling bone resorption to energy metabolism.
