Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Joseph S. Bednash; Nathaniel Weathington; James Londino; Mauricio Rojas; Dexter L. Gulick; Robert Fort; SeungHye Han; Alison C. McKelvey; Bill B. Chen; Rama K. Mallampalli

doi:10.1038/ncomms15203

Nature Communications (May 2017)

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Joseph S. Bednash,
Nathaniel Weathington,
James Londino,
Mauricio Rojas,
Dexter L. Gulick,
Robert Fort,
SeungHye Han,
Alison C. McKelvey,
Bill B. Chen,
Rama K. Mallampalli

Affiliations

Joseph S. Bednash: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Nathaniel Weathington: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
James Londino: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Mauricio Rojas: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Dexter L. Gulick: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Robert Fort: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
SeungHye Han: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Alison C. McKelvey: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Bill B. Chen: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore
Rama K. Mallampalli: Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, UPMC Montefiore

DOI: https://doi.org/10.1038/ncomms15203
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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