Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson’s disease carrying variants in PRKN and HTRA2

Yubo Yan; Suihan Wu; Lixiang Jiang; Bo Yang; Xuhui Chen; Yuqing Liu; Baorong Yu; Jian Fu; Jin Yu; Hui Ning; Meng Chu; Jiayin Yang

Stem Cell Research (Aug 2020)

Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson’s disease carrying variants in PRKN and HTRA2

Yubo Yan,
Suihan Wu,
Lixiang Jiang,
Bo Yang,
Xuhui Chen,
Yuqing Liu,
Baorong Yu,
Jian Fu,
Jin Yu,
Hui Ning,
Meng Chu,
Jiayin Yang

Affiliations

Yubo Yan: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Suihan Wu: Department of Obstetrics, Qingdao Municipal Hospital, Qingdao 266000, China
Lixiang Jiang: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Bo Yang: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Xuhui Chen: Department of Neurology, Peking University Shenzhen Hospital, Shenzhen 518000, China
Yuqing Liu: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Baorong Yu: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Jian Fu: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China
Jin Yu: Department of Obstetrics, Qingdao Municipal Hospital, Qingdao 266000, China
Hui Ning: Department of Obstetrics, Qingdao Municipal Hospital, Qingdao 266000, China
Meng Chu: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China; Corresponding authors at: Room 115, Incubation Block A, Taohuayuan Science and Technology Innovation Park, Bao’an District, Shenzhen 518101, China.
Jiayin Yang: Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China; Cell Inspire Therapeutics Co., Ltd., Shenzhen 518101, China; Corresponding authors at: Room 115, Incubation Block A, Taohuayuan Science and Technology Innovation Park, Bao’an District, Shenzhen 518101, China.

Journal volume & issue: Vol. 47
p. 101905

Abstract

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Variations in PRKN or HTRA2 are associated with Parkinson’s disease. We generated a human induced pluripotent stem cell (iPSC) line CIBi007-A from a patient with young-onset Parkinson’s disease (YOPD) who carried variants in PRKN and HTRA2. The generated iPSCs resembled human embryonic stem cells, expressed pluripotency markers, exhibited a normal karyotype, and could be differentiated into three germ layers in vitro. This line will be valuable for investigating disease mechanisms of YOPD and screening candidate drugs.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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