An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis

Hualiang Pi; Andy Weiss; Clare L. Laut; Caroline M. Grunenwald; Hannah K. Lin; Xinjie I. Yi; Devin L. Stauff; Eric P. Skaar

doi:10.1038/s41467-022-29209-4

Nature Communications (Mar 2022)

An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis

Hualiang Pi,
Andy Weiss,
Clare L. Laut,
Caroline M. Grunenwald,
Hannah K. Lin,
Xinjie I. Yi,
Devin L. Stauff,
Eric P. Skaar

Affiliations

Hualiang Pi: Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center
Andy Weiss: Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center
Clare L. Laut: Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center
Caroline M. Grunenwald: Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center
Hannah K. Lin: Department of Biology, Grove City College
Xinjie I. Yi: Department of Biology, Grove City College
Devin L. Stauff: Department of Biology, Grove City College
Eric P. Skaar: Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center

DOI: https://doi.org/10.1038/s41467-022-29209-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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HitRS is a two-component system that responds to cell envelope damage in the bacterium Bacillus anthracis. Here, the authors identify an RNA-binding protein that regulates HitRS function by modulating the stability of the hitRS mRNA. In addition, the protein binds to over 70 RNAs and affects the expression of genes involved in multiple cellular processes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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