The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions
Hai-Dong Wang,
Chao-Liang Lv,
Lei Feng,
Jin-Xiu Guo,
Shi-Yuan Zhao,
Pei Jiang
Affiliations
Hai-Dong Wang
Department of Pharmacy, The Affiliated Lianyungang Hospital of Xuzhou Medical University/Nanjing Medical University Kangda College First Affiliated Hospital/The First People's Hospital of Lianyungang, Lianyungang, 222000, China
Chao-Liang Lv
Department of Spine Surgery, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China
Lei Feng
Department of Neurosurgery, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Corresponding author. Department of Neurosurgery, Jining First People's Hospital, Shandong First Medical University, No. 6, Jiankang Road, Jining, Shandong, 272000, China.
Jin-Xiu Guo
Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China
Shi-Yuan Zhao
Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China
Pei Jiang
Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China; Corresponding author. Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, No. 6, Jiankang Road, Jining, Shandong, 272000, China.
Effective management of cellular components is essential for maintaining brain health, and studies have identified several crucial biological processes in the brain. Among these, autophagy and the role of exosomes in cellular communication are critical for brain health and disease. The interaction between autophagy and exosomes in the nervous system, as well as their contributions to brain damage, have garnered significant attention. This review summarizes that exosomes and their cargoes have been implicated in the autophagy process in the pathophysiology of nervous system diseases. Furthermore, the onset and progression of neurological disorders may be affected by autophagy regulation of the secretion and release of exosomes. These findings may provide new insights into the potential mechanism by which autophagy mediates different exosome secretion and release, as well as the valuable biomedical applications of exosomes in the prevention and treatment of various brain diseases by targeting autophagy.
