Role of biochemical parameters in predicting the severity of disease in patients with Covid-19

Abstract

Background: The world is currently witnessing a drastic disruption of everyday life due to the rapid progression of the corona virus disease 2019 (COVID-19) pandemic. However, the information on risk factors predicting the prognosis and mortality due to covid-19 is limited. Objectives: To find the levels of serum CRP, D-Dimer, and LDH in confirmed Covid-19 patients and compare their levels in patients who do not require invasive mechanical ventilation (IMV) and with patients required IMV for the treatment management. Methods: A Cross sectional study was carried out on 106 confirmed cases of Covid-19, in whom Random blood sugar (RBS), Creatinine, Urea, C- reactive protein (CRP), D-Dimer and Lactate Dehydrogenase (LDH) were measured. Results: To assess the clinical utility of CRP, D-Dimer and LDH for predicting hospital outcome in Covid-19 Patients, they were divided into two groups, Group I were Covid-19 Patients who did not require ventilation and Group II Covid-19 patients needed invasive mechanical ventilation for the management. CRP and D-Dimer levels were significantly increased with p value <0.05 in group II when compared to group I, but the levels of LDH did not show a statistical significant difference in group I and group II. Conclusion: Our study advocates that determination of biochemical parameters like CRP, D-Dimer and LDH at the time of hospitalization helps in predicting the severity of disease and need for IMV leading to better treatment management and prevention of adverse outcome.

Keywords

• covid-19
• c- reactive protein
• d-dimer and lactate dehydrogenase
• severe acute respiratory syndrome