The Function of the Active Site Glutamate in Human Dihydrofolate Reductase

• Blakley R. L.,
• Appleman J. R.,
• Tsay J. T.,
• Beard W. A.,
• Freisheim J. H.,
• Ayling J. E.,
• Jablonsky M. J.

Affiliations

Blakley R. L.

Department of Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, U.S.A.

Appleman J. R.

Department of Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, U.S.A.

Tsay J. T.

Department of Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, U.S.A.

Beard W. A.

Department of Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee 38105, U.S.A.

Freisheim J. H.

Department of Biochemistry, Medical College of Ohio, Toledo, Ohio, U.S.A.

Ayling J. E.

Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama, U. S. A.

Jablonsky M. J.

NMR Core Facility, University of Alabama at Birmingham, Birmingham, Alabama, U. S.A.