Pakistan Journal of Analytical & Environmental Chemistry (Dec 2009)

Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples

  • Abdul Rauf Khaskheli,
  • Sirajuddin,
  • Kamran Abro,
  • S. T. H. Sherazi,
  • H. I. Afridi,
  • S. A. Mahesar,
  • Munawar Saeed

Journal volume & issue
Vol. 10, no. 1-2
pp. 53 – 58

Abstract

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This work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic drugs were studied for a 5µg ml-1 solution of DS at 276 nm. Under optimized parameters, a linear working range of 0.1–30 g ml-1 with regression coefficient of 0.9998 and lower detection limit of 0.01 g ml-1 was obtained. The method was applied for DS contents in tablets, serum and urine samples.

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