BREACH OF SKIN BARRIER AS A LEADING FACTOR IN THE FORMATION OF LOCAL INFLAMMATORY PROCESS IN ATOPIC DERMATITIS.

Abstract

Atopic dermatitis (also known as infantile eczema, atopic eczema) is a chronic inflammatory skin disease, accompanied by intense itching and continuously relapsing eczematous lesions. Despite the fact that the disease most often begins in early childhood, it is also quite widespread among adults. The disease is often accompanied by a fairly severe psychoemotional stress in both patients and their families, increases the risk of seasonal allergic rhinitis and asthma. Pathogenesis of atopic dermatitis is based on an imbalance in the proliferation of T lymphocytes towards the proliferation of Type 2 T helper cells with a high IgE response to allergens penetrating into the deep layers of the skin. A significant role is attributed to the colonization of the affected skin with Staphylococcus aureus. At present time, the disease is deemed to be an incurable condition, in which the failure of the epidermal barrier is considered to be the leading cause of onset of the disease. Prevention of breaches of the skin barrier, treatment of exacerbations of immuno-mediated inflammation of the skin with corticosteroids along with calcineurin inhibitors in the second line of therapy, as well as control of Staphylococcus skin infections retain their relevance.

Keywords

• atopic dermatitis
• skin barrier
• staphylococcus
• hormones
• topical treatment