Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo

Guilherme Ventura; Aboutaleb Amiri; Raghavan Thiagarajan; Mari Tolonen; Amin Doostmohammadi; Jakub Sedzinski

doi:10.1038/s41467-022-34165-0

Nature Communications (Oct 2022)

Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo

Guilherme Ventura,
Aboutaleb Amiri,
Raghavan Thiagarajan,
Mari Tolonen,
Amin Doostmohammadi,
Jakub Sedzinski

Affiliations

Guilherme Ventura: The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
Aboutaleb Amiri: Max Planck Institute for the Physics of Complex Systems
Raghavan Thiagarajan: The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
Mari Tolonen: The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen
Amin Doostmohammadi: The Niels Bohr Institute, University of Copenhagen
Jakub Sedzinski: The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Copenhagen

DOI: https://doi.org/10.1038/s41467-022-34165-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Cell integration is a critical process in shaping complex tissues. Ventura and Amiri et al. reveal how multiciliated cells exert forces using filopodia to probe and remodel the neighboring cells, facilitating the formation of a susceptible environment for their integration in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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