Nature Communications (Jun 2021)

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

  • Meetali Singh,
  • Eric Cornes,
  • Blaise Li,
  • Piergiuseppe Quarato,
  • Loan Bourdon,
  • Florent Dingli,
  • Damarys Loew,
  • Simone Proccacia,
  • Germano Cecere

DOI
https://doi.org/10.1038/s41467-021-23615-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.