Expression of E-cadherin and B-cell lymphoma 2 in oral cancer: A ratio-based planning for targeted therapy

Abstract

Background: Oral cancer is known to be governed by the antiapototic and loss of cell adhesion properties which dictate its progression. Aim: To study the immunexpression of E-cadherin and Bcl-2 in varying TNM stages and histopathological grades of OSCC. Materials and Methods: 11 cases of well differentiated, 10 cases of moderately differentiated and 11 cases of poorly differentiated OSCC were studied immunohistochemically using archival paraffin embedded tissue specimens. Statistical Analysis: Differences between the different variables were analyzed using ANOVA test, Kruskal–Wallis test and post hoc test followed by Bonferroni test. The resulting data was analyzed using SPSS software version 19. Results: The expression of Bcl-2 and E cadherin immunopositivity was associated positively with tumor grade, high T category and Histopathological grades. Conclusions: The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC.

Keywords

• B-cell lymphoma 2
• E-cadherin
• oral squamous cell carcinoma
• prognosis