Radiation-induced gliosarcoma post-treatment for a recurrent pituitary adenoma: A case report

Abstract

Gliosarcoma is a subtype of glioblastoma containing both gliomatous and sarcomatous components. It constitutes 2–8% of all glioblastoma. It usually affects adults in the 40–60 age group, with a higher incidence among males. Gliosarcoma may arise de-novo or be secondarily induced post-irradiation, the latter being termed secondary gliosarcoma. Radiation-induced sarcoma (RIS) is a rare entity and has an incidence of 0.03–0.3% as a late complication of irradiation. We present an infrequent case of a 55-year-old female who underwent multiple surgeries for recurrent pituitary adenoma followed by post-operative radiation. The patient presented with a recurrence of the adenoma along with a new lesion in the adjacent left temporal region that was suggestive of RIS.

Keywords

• Gliosarcoma
• Radiation-induced
• Recurrent
• Pituitary adenoma