Projeto e construção de um picnômetro a ar para caracterização de insumos e produtos farmacêuticos Project and construction of an air pycnometer to characterization of pharmaceutical raw materials

Abstract

This paper describes a project, construction and test of a low cost air pycnometer, developed to be used preferentially in pharmaceutical research. A complete discussion of the construction, test and calibration of this equipment is presented and some measurements are made using pharmaceutical powders and dry granulations. The equipment performance has been estimated through its calibration curve, and the obtained value to its volume resolution is about 1%. This equipment is accomplished at the Applied Nuclear Physics Laboratory of University of Sorocaba (LAFINAU) in Sorocaba, SP, Brazil and it was denominated "Picnômetro a Ar Uniso - PICNAU".

Keywords

• air pycnometer
• pharmaceutical powders
• project and construction