Involvement of G-quadruplex regions in mammalian replication origin activity

Paulina Prorok; Marie Artufel; Antoine Aze; Philippe Coulombe; Isabelle Peiffer; Laurent Lacroix; Aurore Guédin; Jean-Louis Mergny; Julia Damaschke; Aloys Schepers; Christelle Cayrou; Marie-Paule Teulade-Fichou; Benoit Ballester; Marcel Méchali

doi:10.1038/s41467-019-11104-0

Nature Communications (Jul 2019)

Involvement of G-quadruplex regions in mammalian replication origin activity

Paulina Prorok,
Marie Artufel,
Antoine Aze,
Philippe Coulombe,
Isabelle Peiffer,
Laurent Lacroix,
Aurore Guédin,
Jean-Louis Mergny,
Julia Damaschke,
Aloys Schepers,
Christelle Cayrou,
Marie-Paule Teulade-Fichou,
Benoit Ballester,
Marcel Méchali

Affiliations

Paulina Prorok: Institute of Human Genetics, CNRS-University of Montpellier
Marie Artufel: Aix Marseille Univ, INSERM, TAGC
Antoine Aze: Institute of Human Genetics, CNRS-University of Montpellier
Philippe Coulombe: Institute of Human Genetics, CNRS-University of Montpellier
Isabelle Peiffer: Institute of Human Genetics, CNRS-University of Montpellier
Laurent Lacroix: Balasubramanian group, Department of Chemistry, University of Cambridge
Aurore Guédin: ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB)
Jean-Louis Mergny: ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB)
Julia Damaschke: Research Unit Gene Vectors, Helmholtz Zentrum München (GmbH), German Research Center for Environmental Health
Aloys Schepers: Research Unit Gene Vectors, Helmholtz Zentrum München (GmbH), German Research Center for Environmental Health
Christelle Cayrou: Institute of Human Genetics, CNRS-University of Montpellier
Marie-Paule Teulade-Fichou: CMIB Laboratory, Institut Curie, Campus Universitaire
Benoit Ballester: Aix Marseille Univ, INSERM, TAGC
Marcel Méchali: Institute of Human Genetics, CNRS-University of Montpellier

DOI: https://doi.org/10.1038/s41467-019-11104-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

Origins of replications are associated with potential G quadruplexes forming structures (G4s). Here the authors reveal the functional role of G4 elements in DNA replication initiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal